广西师范大学学报（自然科学版） ›› 2025, Vol. 43 ›› Issue (3): 183-192.doi: 10.16088/j.issn.1001-6600.2024031306

• 分子生物学与生物技术 • 上一篇    下一篇

对香豆酸缓解痛风的效果及作用机制研究

孙建梅, 杨雁, 宋一之, 沈周阳, 唐宗湘*   

  1. 南京中医药大学医学院,江苏南京 210023
  • 收稿日期:2024-03-13 修回日期:2024-04-11 出版日期:2025-05-05 发布日期:2025-05-14
  • 通讯作者: 唐宗湘(1964—), 男, 湖南会同人, 南京中医药大学教授,博导。E-mail:zongxiangtang1@163.com
  • 基金资助:
    江苏省研究生科研与实践创新计划项目(021093002695)

Mitigating Effect and Mechanism of p-Coumaric Acid on Gout

SUN Jianmei, YANG Yan, SONG Yizhi, SHEN Zhouyang, TANG Zongxiang*   

  1. School of Medicine, Nanjing University of Chinese Medicine, Nanjing Jiangsu 210023, China
  • Received:2024-03-13 Revised:2024-04-11 Online:2025-05-05 Published:2025-05-14

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摘要： 痛风是一种以下肢剧烈疼痛为典型特征的急性炎症性关节炎。目前临床治疗痛风的药物,例如秋水仙碱、非甾体抗炎药等均有较大副作用,所以探究一种新型有效且副作用小的治疗药物极为迫切。对香豆酸作为一种具有广泛药理活性的中药成分,是一种极具潜力的治疗痛风药物,但其具体机制尚未明确。本文以小鼠急性痛风性关节炎为模型,探究对香豆酸对痛风的缓解效果及其作用机制。研究发现,对香豆酸能明显缓解急性痛风性疼痛,其可能的作用机制为:一是抗炎,对香豆酸能够明显降低急性痛风模型小鼠关节组织中IL-1β的水平;二是对香豆酸与TRPV1结合,通过抑制TRPV1的功能与表达缓解急性痛风性疼痛。

关键词: 痛风, 对香豆酸, 治疗机制, TRPV1, 热痛

Abstract: Gout is an acute inflammatory arthritis typically characterized by severe pain in the lower limbs. The current clinical treatment of gout, such as colchicine, non-Zithromax anti-inflammatory drugs, and so on, can cause serious side effects.Therefore, it is extremely urgent to explore a new type of effective treatment drug with few side effects. In recent years, traditional Chinese medicine (TCM) has played an advantageous role in the treatment of gout. P-coumaric acid, as a herbal ingredient with a wide range of pharmacological activities, is a highly promising drug for the treatment of gout, but its exact mechanism has not been clarified. In this rearch, mice with acute gouty arthritis were employed as a model to investigate the mitigating effect of p-coumaric acid on gout and to elucidate its potential mechanism. The research results indicates that p-coumaric acid can effectively alleviates acute gout pain. The proposed mechanisms are as follows: firstly, its anti-inflammatory properties are evident as it significantly reduces the production of interleukin-1β (IL-1β) in joint tissues of mice with acute gout. Secondly, p-coumaric acid binds to Transient Receptor Potential Vanilloid 1 (TRPV1), which can alleviate acute gouty pain by inhibiting TRPV1’s function and expression. To conclude, this rearch reveals the potential of p-coumaric acid for the treatment of gout and provides valuable insights into its mechanism of action, paving the way for further clinical applications.

Key words: gout, p-coumaric acid, therapeutic mechanism, TRPV1, thermal pain

中图分类号:  R285

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[1] 郭珺, 陈丹, 朱婵, 唐宗湘. 白芷水提液镇痛作用及其机理研究[J]. 广西师范大学学报（自然科学版）, 2019, 37(4): 103-110.
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