广西师范大学学报（自然科学版） ›› 2012, Vol. 30 ›› Issue (3): 236-243.

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脊髓水平的痒觉神经环路以及信息传递研究进展

唐宗湘, 伍冠一   

  1. 南京中医药大学基础医学院,江苏南京210046
  • 收稿日期:2012-06-02 出版日期:2012-09-20 发布日期:2018-12-04
  • 通讯作者: 唐宗湘(1964—),男,湖南怀化人,南京中医药大学教授,博导。E-mail:tangzx66@hotmail.com
  • 作者简介:唐宗湘,博士,教授,博士研究生导师。
  • 基金资助:
    江苏省特聘教授基金资助项目(013038002001);江苏省自然基金资助项目(012071002242);江苏高校优势学科建设工程资助项目

Progress in Neuronal Circuits and Transmission of Itch in the Spinal Cord

TANG Zong-xiang, WU Guan-yi   

  1. School of Basic Medical Science,Nanjing University of ChineseMedicine,Jiangsu Nanjing 210046,China
  • Received:2012-06-02 Online:2012-09-20 Published:2018-12-04

摘要： 脊髓背角接受痒觉以及痛觉的初级传入。在脊髓背角存在多种神经元并形成杂神经元环路,外周的痒觉信息也在脊髓背角神经元中整合换元并传递到高级中枢。脊髓背角神经元在痒觉信号的传递中发挥重要的作用,本文就脊髓背角神经元的细胞构筑以及痒觉信号传递在脊髓水平的神经回路作简要综述。

关键词: 痒觉, 痛觉, 脊髓, 背角, 神经环路

Abstract: The primary afferents for sensation including pain and itch project inthe dorsal horn of spinal cord.There are some kinds of neurons and they form acomplicated neuronal circuits in the dorsal horn of spinal cord where peripheral pruritus intergrates in and ascend to the high central.The neurons in the dorsal horn of spinal cord play an important role in the itch transmission.Thisreview summarized some significant progresses in the studies of dorsal horncytoarchitecture of spinal cord and neuronal circuits of itch in the spinal cord.

Key words: itch, pain, spinal, dorsal horn, neuronal circuit

中图分类号: 

  • Q42
[1] TODD A J.Neuronal circuitry for pain processing in the dorsal horn[J].Nature Reviews Neuroscience,2010,11(12):823-836.
[2] SCHMELZ M,SCHMIDT R,BICKEL A,et al.Specific C-receptors for itchin human skin[J].The Journal of Neuroscience,1997,17(20):8003-8008.
[3] NAMER B,CARR R,JOHANEK L M,et al.Separate peripheral pathways forpruritus in man[J].Journal of Neurophysiology,2008,100(4):2062-2069.
[4] Al GHAMDI K S,POLGAR E,TODD A J.Soma size distinguishes projection neurons from neurokinin 1 receptor-expressing interneurons in lamina Ⅰ ofthe rat lumbar spinal dorsal horn[J].Neuroscience,2009,164(4):1794-1804.
[5] GRUDT T J,PERL E R.Correlations between neuronal morphology and electrophysiological features in the rodent superficial dorsal horn[J].The Journal of Physiology,2002,540:189-207.
[6] YASAKA T,TIONG S Y,HUGHES D I,et al.Populations of inhibitory andexcitatory interneurons in lamina Ⅱ of the adult rat spinal dorsal horn revealed by a combined electrophysiological and anatomical approach[J].Pain,2010,151(2):475-488.
[7] MAXWELL D J,BELLE M D,CHEUNSUANG O,et al.Morphology of inhibitoryand excitatory interneurons in superficial laminae of the rat dorsal horn[J].The Journal of Physiology,2007,584:521-533.
[8] SPIKE R C,PUSKAR Z,ANDREW D,et al.A quantitativeand morphological study of projection neurons in lamina Ⅰ of the rat lumbar spinal cord[J].The European Journal of Neuroscience,2003,18(9):2433-2448.
[9] TODD A J,PUSKAR Z,SPIKE R C,et al.Projection neurons in lamina Ⅰ of rat spinal cord with the neurokinin 1 receptorare selectively innervated by substance P-containing afferents and respond to noxious stimulation[J].The Journal of Neuroscience,2002,22(10):4103-4113.
[10] TODD A J,McGILL M M,SHEHAB S A.Neurokinin 1 receptorexpressionby neurons in laminae Ⅰ,Ⅲ and Ⅳ of the rat spinal dorsal horn that project to the brainstem[J].The European Journal of Neuroscience,2000,12(2):689-700.
[11] POLGA′R E,CAMPBELL A D,MacINTYREL M,et al.Phosphorylation of ERK in neurokinin 1 receptor-expressing neurons in laminae Ⅲ and Ⅳ of the ratspinal dorsal horn following noxious stimulation[J].Molecular Pain,2007,3:4.
[12] POLGA′R E,Al-KHATER K M,SHEHABS,et al.Large projection neurons in lamina Ⅰ of the rat spinal cord that lack the neurokinin1 receptor are densely innervated by VGLUT2-containing axons and possess GluR4-containing AMPA receptors[J].The Journal of Neuroscience,2008,28(49):13150-13160.
[13] PRESCOTT S A,De KONINCK Y.Four cell types with distinctive membrane properties and morphologies in lamina Ⅰ of the spinal dorsal horn of the adult rat[J].The Journal of Physiology,2002,539:817-836.
[14] HAN Z S,ZHANG E T,CRAIG A D.Nociceptive and thermoreceptive lamina Ⅰ neurons are anatomically distinct[J].Nature Neuroscience,1998,1(3):218-225.
[15] Al-KHATER K M,TODD A J.Collateral projections ofneurons inlaminae Ⅰ,Ⅲ,and Ⅳ of rat spinal cord to thalamus,periaqueductal gray matter,and lateral parabrachial area[J].The Journal of Comparative Neurology,2009,515(6):629-646.
[16] RUSCHEWEYH R,IKEDA H,HEINKE B,et al.Distinctive membrane and discharge properties of rat spinal lamina Ⅰ projection neurones in vitro[J].The Journal of Physiology,2004,555:527-543.
[17] YASAKA T,KATO G,FURUE H,et al.Cell-type-specific excitatory andinhibitory circuits involving primary afferents in the substantia gelatinosa of the ratspinal dorsal horn in vitro[J].The Journal of Physiology,2007,581:603-618.
[18] KIM A Y,TANG Zong-xiang,LIU Qin,et al.Pirt,a phosphoinositide-binding protein,functions as a regulatory subunit of TRPV1[J].Cell,2008,133(3):475-485.
[19] UTA D,FURUE H,PICKERING A E,et al.TRPA1-expressing primary afferents synapse with a morphologically identified subclass of substantia gelatinosa neuronsin the adult rat spinal cord[J].The European Journal of Neuroscience,2010,31(11):1960-1973.
[20] LU Yan,PERL E R.A specific inhibitory pathway between substantia gelatinosa neurons receiving direct C-fiber input[J].The Journal of Neuroscience,2003,23(25):8752-8758.
[21] ZHENG J,LU Y,PERL E R.Inhibitory neurones of the spinal substantia gelatinosa mediate interaction of signals from primary afferents[J].The Journal of Physiology,2010,588:2065-2075.
[22] CARSTENS E.Responses of rat spinal dorsal horn neurons to intracutaneousmicro injection of histamine,capsaicin,and other irritants[J].Journal of Neurophysiology,1997,77(5):2499-2514.
[23] JINKS S L,CARSTENS E.Superficial dorsal horn neurons identified by intracutaneous histamine:chemonociceptive responses and modulation bymorphine[J].Journal of Neurophysiology,2000,84(2):616-627.
[24] ANDREW D,CRAIG A D.Spinothalamic lamina Ⅰ neurons selectively sensitive to histamine:a central neural pathway for itch[J].Nature Neuroscience,2001,4(1):72-77.
[25] SIMONE D A,ZHANG X,LI J,et al.Comparison of responses of primatespinothalamic tract neurons to pruritic and algogenic stimuli[J].Journal of Neurophysiology,2004,91(2):213-222.
[26] DAVIDSON S,ZHANG Xi-jing,YOON C H,et al.The itch-producing agents histamine and cowhage activate separate populations of primate spinothalamic tract neurons[J].The Journal of Neuroscience,2007,27(37):10007-10014.
[27] LIU Qin,TANG Zong-xiang,SURDENIKOVA L,et al.Sensory neuron-specific GPCR mrgprs are itch receptors mediating chloroquine-induced pruritus[J].Cell,2009,139(7):1353-1365.
[28] SUN Yan-gang,CHEN Zhou-feng.A gastrin-releasing peptide receptor mediates the itch sensation in the spinal cord[J].Nature,2007,448:700-703.
[29] SUN Yan-gang,ZHAO Zhong-qiu,MENG Xiu-li,et al.Cellular basis of itch sensation[J].Science,2009,325(5947):1531-1534.
[30] MA Q.Labeled lines meet and talk:population coding of somaticsensations[J].The Journal of Clinical Investigation,2010,120(11):3773-3778.
[31] ROSS S E,MARDINLY A R,McCORD A E,et al.Loss of inhibitory interneurons in the dorsal spinal cord and elevated itch in Bhlhb5 mutant mice[J].Neuron,2010,65(6):886-898.
[32] LAGERSTRÖM M C,ROGOZ K,ABRAHAMSEN B,et al.VGLUT2-dependent sensory neurons in the TRPV1 population regulate pain and itch[J].Neuron,2010,68(3):529-542.
[33] LIU Yang,SAMAD O A,ZHANG Ling,et al.VGLUT2-dependent glutamate release from nociceptorsis required to sense pain and suppress itch[J].Neuron,2010,68(3):543-556.
[34] JEFFRY J,KIM S,CHEN Z F.Itch signaling in the nervous system[J].Physiology (Bethesda),2011,26(4):286-292.
[35] CEVIKBAS F,STEINHOFF M,IKOMA A.Role of spinal neurotransmitterreceptors in itch:new insights into therapies and drug development[J].CNS Neurosciences & Therapeutics,2011,17(6):742-749.
[36] KOGA K,CHEN T,LI X Y,et al.Glutamate acts as a neurotransmitterfor gastrin releasing peptide-sensitive and insensitive itch-related synaptic transmission in mammalian spinal cord[J].Molecular Pain,2011,7:47.
[37] IKOMA A,CEVIKBAS F,KEMPKES C,et al.Anatomy and neurophysiology of pruritus[J].Seminars in Cutaneous Medicine and Surgery,2011,30(2):64-70.
[38] LIU Xian-yu,LIU Zhong-chun,SUN Yan-gang,et al.Unidirectional cross-activation of GRPR by MOR1D uncouples itch and analgesia induced by opioids[J].Cell,2011,147:447-458.
[39] MANTYH P W,ROGERS S D,HONORE P,et al.Inhibitionof hyperalgesia by ablation of lamina Ⅰ spinal neurons expressing the substance P receptor[J].Science,1997,278(5336):275-279.
[40] ANDOH T,NAGASAWA T,SATOH M,et al.Substance Pinductionof itch-associated response mediated by cutaneous NK1 tachykinin receptors in mice[J].The Journal of Pharmacology and Experimental Therapeutics,1998,286(3):1140-1145.
[41] CARSTENS E E,CARSTENS M I,SIMONS C T,et al.Dorsal horn neurons expressing NK-1 receptors mediate scratching in rats[J].Neuroreport,2010,21(4):303-308.
[42] SMITH E S,BLASS G R,LEWIN G R,et al.Absence ofhistamine-induced itch in the African naked mole-rat and “rescue” by Substance P[J].Molecular Pain,2010,6:29.
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