广西师范大学学报（自然科学版） ›› 2012, Vol. 30 ›› Issue (4): 110-114.

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HIV-1感染者血清IL-18及IL-18BP水平的变化及临床意义

黄甲清1, 张英1, 蒋就喜1, 胡婷婷1, 李赫伟1, 曾思恩1, 徐茹2, 沈建峰3, 谢付静4   

  1. 1.桂林医学院附属医院,广西桂林 541001;
    2.桂林市第三人民医院,广西桂林 541001;
    3.淮南市东方医院集团总院,安徽淮南 232007;
    4.聊城市人民医院,山东聊城 252000
  • 收稿日期:2012-04-27 发布日期:2018-11-27
  • 通讯作者: 蒋就喜(1955—),男,广西桂林人,桂林医学院教授,硕士生导师。E-mail:gljiangjx@sohu.com
  • 基金资助:
    国家自然科学基金资助项目(30460141);广西本级技术研究与开发项目(桂财教[2010]124号,桂财教[2012]98号);广西教育厅科研项目(桂教科研[2007]34号);广西医疗卫生重点科研课题基金资助项目(重2010055);桂林市科学研究与技术开发项目(市科[2010]37号)

Clinical Significance of Changes of Interleuking-18 and Interleuking-18 Binding Protein Levels in Serum of HIV-infected Patients

HUANG Jia-qing1, ZHANG Ying1, JIANG Jiu-xi1, HU Ting-ting1, LI He-wei1, ZENG Si-en1, XU Ru2, SHEN Jian-feng3, XIE Fu-jing4   

  1. 1.Affiliated Hospital of Guilin Medical College,Guilin Gugnaxi541004,China;
    2.The Third People's Hospital of Guilin,Guilin Guangxi 541001,China;
    3.The General Hospital of Huainan Eastern Hospital Group,Huainan Anhui 232007,China;
    4.Liaocheng People's Hospital,Liaocheng Shandong 252000,China
  • Received:2012-04-27 Published:2018-11-27

摘要： 为了观察HIV-1阳性病人血清IL-18和IL-18BP水平与疾病的关系,用ELISA法检测67例经HAART治疗的HIV-1阳性病人及18例正常对照者血清的IL-18和IL-18BP水平。结果显示,HIV-1感染组血清IL-18水平明显高于正常对照组(P＜0.01),其中A类HIV-1感染组IL-18水平高于正常对照组(P＜0.05),B类、C类HIV-1感染组IL-18水平明显高于正常对照组(P＜0.01);HIV-1感染组血清IL-18BP的水平明显高于正常人(P＜0.01),其中各类HIV-1感染组IL-18BP水平均高于正常对照组(P＜0.05);正常对照组IL-18和IL-18BP水平呈正相关(r=0.705,P＜0.01),HIV-1感染组的IL-18和IL-18BP水平无相关性。可见,IL-18和IL-18BP水平的变化及失衡与艾滋病的发生、发展相关,动态监测外周血IL-18及IL-18BP水平可作为反映HIV-1感染者的免疫功能状态变化指标,调节体内IL-18、IL-18BP水平的平衡可能为艾滋病治疗提供新途径。

关键词: HIV-1, 白细胞介素-18, 白细胞介素-18结合蛋白

Abstract: To investigate the clinical significance and changes of IL-18and IL-18BP in serum in HIV-infected patients,the levels of IL-18and IL-18BP in serum were detected by ELISA in 67 cases of HIV-1 infestors with HAART and 18 cases of healthy persons.The levels of IL-18 in serum of HIV-1group were significantly higher than those of control group (P＜0.01),the levels of IL-18 in serum of HIV-1 group A were higher than those of control group (P＜0.05);Thelevels of IL-18 in serum of HIV-1 group B and HIV-1 group C were significantly higher thanthose of control group (P＜0.01);The levels of IL-18BP in serum of HIV-1 group were significantly higher than those of control group (P＜0.01),the levels ofIL-18 in serum of three HIV-1 groups were higher than those of control group (P＜0.05);A significant positive correlation was found between the levelsof IL-18 and IL-18BP in healthy persons (r=0.705,P＜0.01).The levels of IL-18 had nocorrelation with the levels of IL-18BP in serum of three HIV-1 groups.Increased levels of IL-18 and IL-18BP may play important roles in the occurrence and progression of AIDS,and the imbalance between IL-18 and IL-18BP may participatein it too.Dynamic monitoring of IL-18 and IL-18 BP in peripheral blood can beused as a reflection of the immune function of state changes index in HIV-1 infected patients.Regulating the balance between IL-18 and IL-18 BP may providea new approach for the treatment of AIDS.

Key words: HIV-1, Interleukin-18, Interleukin-18 binding protein

中图分类号: 

  • R512.91
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