广西师范大学学报（自然科学版） ›› 2016, Vol. 34 ›› Issue (4): 151-155.doi: 10.16088/j.issn.1001-6600.2016.04.023

• 广西高校优秀中青年骨干教师培养工程论坛 • 上一篇    下一篇

慢性吸烟者的脑静息态fMRI局部一致性研究

刘佳丽1,王冬翠2,莫少锋3,李宏周1,陈真诚1   

  1. 1.桂林电子科技大学生命与环境科学学院,广西桂林541004;
    2.中南大学湘雅医院,湖南长沙410008;
    3. 中南大学地球科学与信息物理学院,湖南长沙410083
  • 出版日期:2016-07-18 发布日期:2018-07-18
  • 通讯作者: 陈真诚(1965—),男,湖南永州人,桂林电子科技大学教授,博士。E-mail:chenzhcheng@163.com
  • 基金资助:
    国家自然科学基金资助项目(61271119);国家科技支撑计划基金资助项目(2013BAI03B01)

Alterations in Regional Homogeneity of Resting-state Brain Activity in Chronic Cigarette Smokers

LIU Jiali1, WANG Dongcui2, MO Shaofeng3, LI Hongzhou1, CHEN Zhencheng1   

  1. 1.School of Life and Environmental Sciences, Guilin University of Electronic Technology, Guilin, Guangxi 541004, China;
    2. Xiangya Hospital, Central South University, Changsha Hunan 410008, China;
    3. School of Geosci and Info-physics, Central South University, Changsha Hunan 410083, China
  • Online:2016-07-18 Published:2018-07-18

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摘要： 为了纵向研究慢性吸烟者在未戒烟和戒烟一段时间后静息态局部脑功能活动发生的变化,本文结合功能磁共振成像(fMRI)和局部一致性(ReHo)方法,对12名慢性吸烟的健康志愿者,在未戒烟和戒烟一周后的脑静息态扫描数据进行组内比较分析,结果:与未戒烟状态相比,吸烟者戒烟一周后额叶(左侧眶内额叶、右侧额中回、右侧背外侧额叶)、左侧楔前叶、左侧后扣带皮层、左侧楔叶和右侧初级运动皮层的ReHo显著降低;双侧颞上回、左侧距状裂沟回、左侧舌回、左侧梭状回、左侧海马旁回、右侧中央后回和左侧豆状壳核的ReHo显著增强。研究表明,慢性吸烟者在戒烟一周后上述脑区的神经元活动一致性发生了变化,这为ReHo应用于戒烟疗法提供了一定依据。

关键词: 慢性吸烟, 静息态功能磁共振成像, 局部一致性, 戒烟

Abstract: Most previously studies on chronic smokers are transversal studies based on task paradigm. In this study, longitudinal studies of regional brain activity alterations between smoking and quitting smoking for some time in resting state are carried. Twelve healthy chronic smokers participated in this study and were imaged with resting state functional magnetic resonance imaging (fMRI) in two stages, i.e., under smoking and after quitting smoking for one week. Then regional homogeneity (ReHo) method was used to conduct a comparative analysis of the statistics of the two stages. Compared with those in smoking state, smokers who had quitted smoking for one week showed decreased level of ReHo in frontal lobe (orbital, medial, middle), left precuneus, left posterior cingulate cortex (PCC), left cuneus, and right supplementary motor area, as well as increased level of ReHo in bilateral superior temporal gyrus, left calcarine, left lingual gyrus, left fusiform gyrus, left parahippocampa gyrus, right postcentral gyrus, and left putamen. The results indicate that coherence of neural activities have been altered in the above brain regions after quitting smoking for one week among the chronic smokers, which offers references for the application of ReHo in smoking cessation therapy.

Key words: chronic smokers, resting-state fMRI, regional homogeneity, smoking cessation

中图分类号: 

  • R395.1
[1] NORMILE D. Public health: a sense of crisis as China confronts ailments of affluence[J]. Science, 2010, 328(5977):422-424.
[2] BRODY A L, MANDELKERN M A, JARVIK M E, et al. Differences between smokers and nonsmokers in regional gray matter volumes and densities[J]. Biological Psychiatry, 2004, 55(1):77-84.
[3] ZHANG X, SALMERON B J, ROSS T J, et al. Anatomical differences and network characteristics underlying smoking cue reactivity[J]. Neuro Image, 2011, 54(1):131-141.
[4] LIAO Y, TANG J, LIU T, et al. Differences between smokers and non-smokers in regional gray matter volumes: a voxel-based morphometry study[J]. Addict Biol, 2012, 17(6):977-980.
[5] 廖艳辉,唐劲松,郝伟,等.基于局部一致性(ReHo)方法的慢性吸烟静息状态功能磁共振(fMRI)研究[J].中国临床心理学杂志,2011,19(4):427-429,436.
[6] STEIN E A, PANKIEWICZ J, HARSCH H H, et al. Nicotine-induced limbic cortical activation in the human brain: a functional MRI study[J]. Am J Psychiatry, 1998, 155(8):1009-1015.
[7] PARK S, KNOPICK C, MCGURK S, et al. Nicotine impairs spatial working memory while leaving spatial attention intact[J]. Neuropsychopharmacology, 2000, 22(2):200-209.
[8] TANG J, LIAO Y, DENG Q, et al. Altered spontaneous activity in young chronic cigarette smokers revealed by regional homogeneity[J]. Behav Brain Funct, 2012,8(1):1-5.
[9] YU R, ZHAO L, TIAN J, et al. Regional homogeneity changes in heavy male smokers: a resting-state functional magnetic resonance imaging study[J]. Addiction Biology, 2013, 18(4):729-731.
[10] PAUL R H, BRICKMAN A M, COHEN R A, et al. Cognitive status of young and older cigarette smokers: Data from the international brain database[J]. Journal of Clinical Neuroscience, 2006, 13(4):457-465.
[11] PINEDA J A, HERRERA C, KANG C, et al. Effects of cigarette smoking and 12-h abstention on working memory during a serial-probe recognition task[J]. Psychopharmacology (Berl), 1998, 139(4):311-321.
[12] FROELIGER B, MODLIN L A, KOZINK R V, et al. Frontoparietal attentional network activation differs between smokers and nonsmokers during affective cognition[J]. Psychiatry Research: Neuroimaging, 2013, 211(1):57-63.
[13] NEWHOUSE P A, POTTER A S, DUMAS J A, et al. Functional brain imaging of nicotinic effects on higher cognitive processes[J]. Biochem Pharmacol, 2011, 82(8):943-951.
[14] LYVERS M, CARLOPIO C, BOTHMA V, et al. Mood, mood regulation expectancies and frontal systems functioning in current smokers versus never-smokers in China and Australia[J]. Addictive Behaviors, 2013, 38(11):2741-2750.
[15] ERNST M, HEISHMAN S J, SPURGEON L, et al. Smoking history and nicotine effects on cognitive performance[J]. Neuropsychopharmacology, 2001, 25(3):313-319.
[16] BEAVER J D, LONG C J, COLE D M, et al. The effects of nicotine replacement on cognitive brain activity during smoking withdrawal studied with simultaneous fMRI/EEG[J]. Neuropsychopharmacology, 2011,36(9):1792-1800.
[17] 王超, 张敏鸣. 尼古丁依赖的脑功能MRI研究进展[J]. 磁共振成像, 2013,4(3):232-235.
[18] 钱微. 吸烟者脑结构的磁共振研究[D]. 杭州:浙江大学, 2014.
[19] 周旭辉, 王绪佚, 郝伟. 尼古丁依赖的功能影像学研究进展[J]. 中国临床心理学杂志, 2007,15(5):489-492.
[20] ZANG Y, JIANG T, LU Y, et al. Regional homogeneity approach to fMRI data analysis[J]. Neuroimage, 2004, 22(1):394-400.
[21] YAN Chaogan, ZANG Yufeng. DPARSF: a MATLAB toolbox for“pipeline”data analysis of resting-state fMRI[J]. Frontiers in Systems Neuroscience, 2010, 4(13):00013.
[22] SONG X W, DONG Z Y, LONG X Y, et al. REST: a toolkit for resting-state functional magnetic resonance imaging data processing[J]. PLoS One, 2011, 6(9):e25031.
[23] DONG G, HUANG J, DU X. Alterations in regional homogeneity of resting-state brain activity in internet gaming addicts[J]. Behavioral and Brain Functions: BBF, 2012, 8(1):41.
[24] MILLER E K, COHEN J D. An integrative theory of prefrontal cortex function[J]. Annual Review of Neuroscience, 2001, 24:167-202.
[25] HONG L E, GU H, YANG Y, et al. Association of nicotine addiction and nicotine′s actions with separate cingulate cortex functional circuits[J]. Arch Gen Psychiatry, 2009, 66(4):431-441.
[26] BIGLER E D, MORTENSEN S, NEELEY E S, et al. Superior temporal gyrus, language function, and autism[J]. Developmental Neuropsychology, 2007, 31(2):217-238.
[27] MARCHAND W R, LEE J N, THATCHER J W, et al. Putamen coactivation during motor task ution[J]. Neuroreport, 2008, 19(9):957-960.
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