广西师范大学学报（自然科学版） ›› 2026, Vol. 44 ›› Issue (5): 16-26.doi: 10.16088/j.issn.1001-6600.2026012101

• 物理与电子工程 • 上一篇    下一篇

复合非晶丝GMI生物传感器对cTnI的灵敏检测

杨真1,2,3,4*, 唐悦1,2,3,4, 耿兆杰1,2,3,4, 殷旭1,2,3,4, 黄永5   

  1. 1.广西类脑计算与智能芯片重点实验室(广西师范大学), 广西 桂林 541004;
    2.广西高校集成电路与微系统重点实验室(广西师范大学), 广西 桂林 541004;
    3.光电信息技术广西高校工程研究中心(广西师范大学), 广西 桂林 541004;
    4.广西师范大学 电子与信息工程学院/集成电路学院, 广西 桂林 541004;
    5.上海永投智创半导体有限公司, 上海 201900
  • 收稿日期:2026-01-21 修回日期:2026-03-11 出版日期:2026-09-05 发布日期:2026-07-24
  • 通讯作者: 杨真(1984—),男,湖北孝感人,广西师范大学副教授,博士。E-mail: zy2020@gxnu.edu.cn
  • 基金资助:
    广西自然科学基金面上项目(2023JJA170157);广西师范大学2025年国家自然科学基金联合培育项目(2025PY046);2022年桂林市重点研发计划项目(20220113-5);广西高校集成电路与微系统重点实验室开放基金(ICM-25-03),2025年研究生课程思政项目《MEMS技术及应用》;横向课题-NiCr薄膜压力传感器研发(RH2500002608)

Giant magnetoimpedance biosensor based on composite amorphous wire for sensitive detection of cTnI

Yang Zhen1,2,3,4*, Tang Yue1,2,3,4, Geng Zhaojie1,2,3,4, Yin Xu1,2,3,4, Huang Yong5   

  1. 1. Guangxi Key Laboratory of Brain-Inspired Computing and Intelligent Chips (Guangxi Normal University), Guilin Guangxi 541004, China;
    2. Guangxi Universities Key Laboratory of Integrated Circuits and Microsystems (Guangxi Normal University), Guilin Guangxi 541004, China;
    3. Guangxi Universities Engineering Research Center for Optoelectronic Information Technology (Guangxi Normal University), Guilin Guangxi 541004, China;
    4. School of Electronics and Information Engineering/School of Integrated Circuits, Guangxi Normal University, Guilin Guangxi 541004, China;
    5. Shanghai Yongtou Zhichuang Semiconductor Co., Ltd., Shanghai 201900, China
  • Received:2026-01-21 Revised:2026-03-11 Online:2026-09-05 Published:2026-07-24

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摘要： 为了提升非晶丝的giant nagnetoimpedance(GMI)性能和灵敏度,本文采用磁控溅射技术制备碳纳米层包覆的Co基复合非晶丝,碳层厚度分别为67、203、334、467和601 nm,系统地研究复合丝的微观结构、磁性能以及不同碳层厚度对巨磁阻抗效应的影响。结果表明,当碳层厚度为334 nm时,复合非晶丝展现出最优的GMI性能,最大GMI比率达522%,相应灵敏度为33.8% Oe-1。基于该高性能复合非晶丝构建GMI生物传感器敏感元件,结合图案化SiO2薄膜构建的生物分子反应界面与聚二甲基硅氧烷(polydimethylsiloxane, PDMS)微流控芯片,通过三明治免疫反应实现对心肌肌钙蛋白I(cardiac troponin I, cTnI)的超灵敏检测。实验结果显示,该传感器在0.001~500 μg/L具有良好的线性响应,检测限低至0.001 μg/L,且表现出优异的特异性、稳定性和抗干扰能力。该研究为基于非晶丝GMI效应的生物检测技术提供了重要支撑。

关键词: 非晶丝, 巨磁阻抗效应, 生物传感器, 心肌肌钙蛋白I, 生物检测

Abstract: In order to enhance the giant magnetoimpedance (GMI) performance and sensitivity of amorphous microwires, this study fabricates carbon nano-layer-coated Co-based composite amorphous microwires by using magnetron sputtering technology. The carbon layer thicknesses are set at 67, 203, 334, 467, and 601 nm, respectively. A systematic investigation is conducted on the microstructure, magnetic properties, and the influence of varying carbon layer thicknesses on the giant magnetoimpedance effect in the composite microwires. The results indicate that the composite amorphous wire with a carbon layer thickness of 334 nm exhibits optimal GMI performance, achieving a maximum GMI ratio of 522% and a corresponding sensitivity of 33.8% Oe-1. By constructing a GMI biosensing element from this high-performance composite amorphous wire and integrating it with a bio-molecular reaction interface based on a patterned SiO2 thin film and a PDMS microfluidic chip, ultrasensitive detection of cardiac troponin I(cTnI) is accomplished via a sandwich immunoassay. Experimental results demonstrate that the sensor exhibits a favorable linear response within the concentration range of 0.001-500 μg/L, with a detection limit as low as 0.001 μg/L, along with outstanding specificity, stability, and anti-interference capability. This study provides significant support for biomolecular detection technology based on the GMI effect in amorphous wires.

Key words: composite amorphous wire, giant magnetoimpedacne effect, biosensor, cardinac troponin I(cTnI), biological detection

中图分类号:  TB33;TP212.3

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