Journal of Guangxi Normal University(Natural Science Edition) ›› 2016, Vol. 34 ›› Issue (1): 162-167.doi: 10.16088/j.issn.1001-6600.2016.01.026

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Chronic Stress Affects the Theta Activity in BLAto Induce the Stress Response in Mice

JIANGFangjie1,2, FU Yu3, WU Guisheng1, YANG Liping 1, 2,4, TANG He1,2, DENG Ke1, LIN Wanhua1,5, LUO Huairong1   

  1. 1.State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming Yunnan 650201,China;
    2.University of Chinese Academy of Sciences, Beijing 100039,China;
    3.Kunming University of Science and Technology, Kunming Yunnan 650093,China;
    4.Yunnan Institute of Traditional Chinese Medicine and Materia Medica, Kunming Yunnan 650223,China;
    5. College of Life Science,Guangxi Normal University, Guilin Guangxi 541006, China
  • Received:2015-05-05 Published:2018-09-14

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Abstract: Chronic exposure to stress triggered many dysfunctional emotional behaviors, like generalized anxiety disorder, depression and bipolar disorder. Prolonged stress led to structural changes in the prefrontal cortex-amygdala-ventral hippocampus emotional circuit and thus exerted anxiety behavioral phenotypes. But the alteration of neural activity for those nucleus that involved in emotional regulation is not clear. So chronic stress model in mice was established local field potential (LFP) were recorded from the basolateral amygdala (BLA) and hippocampal CA3 respectively in freely exploring mouse and separated the signals into alpha, beta, and delta, theta, gamma frequency bands. In contrast to the control groups, in BLA, stress induced a trend of increase of LFP absolute power at these five bands, the increase at delta band was significant. Through further analysis of the LFP relative power, it showed that there was a distinct increase at delta band and a significant decrease at theta band in stressed mice.

Key words: chronic stress,, BLA, CA3, local field potential

CLC Number: 

  • R338.8
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