Journal of Guangxi Normal University(Natural Science Edition) ›› 2019, Vol. 37 ›› Issue (4): 103-110.doi: 10.16088/j.issn.1001-6600.2019.04.013

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Analgesic Effect and Analgesic Mechanism of Angelica dahurica Extracts

GUO Jun, CHEN Dan, ZHU Chan, TANG Zongxiang*   

  1. School of Medicine and Life Sciences, Nanjing University of Chinese Medicine, Nanjing Jiangsu 210023, China
  • Received:2019-02-27 Online:2019-10-25 Published:2019-11-28

Abstract: The analgesic effect of ADE was evaluated by a series of pain models, in which the pain behaviours were induced by tail immersion, thermal radiation, capsaicin and formalin tests, and Von-Frey mechanical stimulation, respectively. The primary cell culture and calcium imaging technique were then employed to investigate the functional mechanism of ADE in neurons from dorsal root ganglion (DRG). The results showed that the ADE substantially attenuated the acute pain induced by thermal, capsaicin, and formalin in mice. However, ADE did not suppress the thermal-or capsaicin-induced acute pain in Trpv1-/- mice. Moreover, ADE significantly inhibited the intracellular influx of Ca2+ induced by capsaicin in the TRPV1-positive DRG neurons. So these findings suggested that ADE exhibits an analgesic effect in pain models by reducing the activity of TRPV1.

Key words: Angelica dahurica, analgesic effect, TRPV1, thermal pain, acute pain

CLC Number: 

  • R282.71
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