Journal of Guangxi Normal University(Natural Science Edition) ›› 2016, Vol. 34 ›› Issue (4): 151-155.doi: 10.16088/j.issn.1001-6600.2016.04.023

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Alterations in Regional Homogeneity of Resting-state Brain Activity in Chronic Cigarette Smokers

LIU Jiali1, WANG Dongcui2, MO Shaofeng3, LI Hongzhou1, CHEN Zhencheng1   

  1. 1.School of Life and Environmental Sciences, Guilin University of Electronic Technology, Guilin, Guangxi 541004, China;
    2. Xiangya Hospital, Central South University, Changsha Hunan 410008, China;
    3. School of Geosci and Info-physics, Central South University, Changsha Hunan 410083, China
  • Online:2016-07-18 Published:2018-07-18

Abstract: Most previously studies on chronic smokers are transversal studies based on task paradigm. In this study, longitudinal studies of regional brain activity alterations between smoking and quitting smoking for some time in resting state are carried. Twelve healthy chronic smokers participated in this study and were imaged with resting state functional magnetic resonance imaging (fMRI) in two stages, i.e., under smoking and after quitting smoking for one week. Then regional homogeneity (ReHo) method was used to conduct a comparative analysis of the statistics of the two stages. Compared with those in smoking state, smokers who had quitted smoking for one week showed decreased level of ReHo in frontal lobe (orbital, medial, middle), left precuneus, left posterior cingulate cortex (PCC), left cuneus, and right supplementary motor area, as well as increased level of ReHo in bilateral superior temporal gyrus, left calcarine, left lingual gyrus, left fusiform gyrus, left parahippocampa gyrus, right postcentral gyrus, and left putamen. The results indicate that coherence of neural activities have been altered in the above brain regions after quitting smoking for one week among the chronic smokers, which offers references for the application of ReHo in smoking cessation therapy.

Key words: chronic smokers, resting-state fMRI, regional homogeneity, smoking cessation

CLC Number: 

  • R395.1
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