Journal of Guangxi Normal University(Natural Science Edition) ›› 2013, Vol. 31 ›› Issue (3): 197-201.

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The Role of DDX17 RNA Helicase in SET8 Response to Wnt Pathway

LI Hong-yan   

  1. School of Medicine,Tibet University for Nationalities,Shaanxi Xianyang 712082,China
  • Received:2013-04-27 Online:2013-09-20 Published:2018-11-26

Abstract: Wnt signaling is composed by a huge network system in which many transcription factors and regulatory proteins are involved in the pathway.The role of the DDX17 RNA helicase in the SET8 response to Wnt signaling by RT-PCR and Co-IP methods is studied.The result preliminary finds that DDX17 is crucial for activation of the Wnt target genes in mammalian cells.Additionally,there is interaction between DDX17s and SET8/TCF4/LEF1/HDAC1.

Key words: Wnt signaling, SET8, DDX17, HDAC1

CLC Number: 

  • Q291
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