Journal of Guangxi Normal University(Natural Science Edition) ›› 2016, Vol. 34 ›› Issue (3): 102-108.doi: 10.16088/j.issn.1001-6600.2016.03.014

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The Anti-Tumor Mechanism of 1,8-Naphthalate FormylImide Derivative NA-17 in HepG2 Cells

WU Yiming1, LI Liangping2, ZENG Shulan2, LI Xiaohong2, ZHOU Zuping1, PENG Yan2   

  1. 1. College of Life Sciences,Guangxi Normal University,Guilin Guangxi 541006,China;
    2. College of Chemistry & Pharmaceutical Sciences,Guangxi Normal University,Guilin Guangxi 541004,China
  • Received:2015-11-24 Online:2016-09-30 Published:2018-09-17

Abstract: The antitumor effects of a novel 1,8-naphthalate formyl imide derivative NA-17 in human liver cancer cells was researched. The inhibition effects of NA-17 in various human cancer cell lines showed that NA-17 exhibited highly selective inhibition in human liver cancer cell line HepG2, but with low toxicity to normal hepatic cell HL-7702. Preliminary research indicated that NA-17 induced apoptosis to suppress proliferation in HepG2 cells. Further studies showed that NA-17 induced the increase in the levels of Bak, while the decrease in Bcl-2 and Bcl-xL to trigger cell apoptosis.

Key words: NA-17, apoptosis, HepG2, selective inhibition, antineoplastic activity

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