Journal of Guangxi Normal University(Natural Science Edition) ›› 2010, Vol. 28 ›› Issue (3): 42-45.

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Determination of Haloperidol in Human Urine by Capillary Electrophoresis Electrochemiluminescence

KANG Yan-hui1,2, ZHU Ting-chun3, HE Hong-mei2, DENG Bi-yang1   

  1. 1. College of Chemistry and Chemical Engineering,Guangxi NormalUniversity,Guilin Guangxi 541004;
    2. College of Medical,Hebei University of Engineering,Handan Hebei 056002,China;
    3. Department of Chemistry,Handan College,Handan Hebei 056005,China
  • Received:2010-06-07 Online:2010-09-20 Published:2023-02-06

Abstract: A novel method of capillary electrophoresis (CE) withtris(2,2′-bipyridyl)ruthenium(Ⅱ) electrochemiluminescence (ECL) detection has been developed for the determination of haloperidol in human urine.The parameters such as workelectrode potential,concentration and pH of phosphate buffer solution on effectof ECL intensity of haloperidol were investigated.Under optimized conditions,haloperidol concentration was linear with ECL peak area in the range of 0.01～10mg·L-1.The detection limit (3σ) for haloperidol was 3.5 μg·L-1,and the RSD was 1.6% for 3.0 mg·L-1 haloperidol (n=11).The recoveries were between 95.0% and 99.5%.

Key words: capillary electrophoresis, electrochemiluminescence, haloperidol, tris(2,2′-bipyridyl)ruthenium(Ⅱ)

CLC Number: 

  • O657.8
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