Journal of Guangxi Normal University(Natural Science Edition) ›› 2019, Vol. 37 ›› Issue (1): 205-210.doi: 10.16088/j.issn.1001-6600.2019.01.024

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99 Cases of Abnormal Chromosome Karyotype Analysis

MU Hui1, OU Minglin2,TANG Dong’e3,ZHANG Ruohan2, HE Huiyan3,LIANG Zhuojian3, ZOU Guimian1,2,DAI Yong3*   

  1. 1.College of Life Sciences, Guangxi Normal University, Guilin Guangxi 541006, China;
    2. Nephrology Department of Guilin No. 181 Hospital, Guangxi Key Laboratory of Metabolic Diseases Research, Guilin Guangxi 541002, China;
    3.Clinical Medical Research Center, the Second Clinical Medical College of Jinan University, Shenzhen Guangdong 518020, China
  • Received:2017-11-28 Online:2019-01-20 Published:2019-01-08

Abstract: To discuss the abnormalities in peripheral blood chromosomal karyotypes and amniotic fluid karyotypes, as well as their application in clinical analysis. Peripheral blood G-banding technique was used to analyze the chromosomal karyotypes of the genetic counseling patients from 181st Hospital of Chinese People’s Liberation Army and Shenzhen People’s Hospital. 1 868 samples of peripheral blood and 541 samples of amniotic fluid were collected for the preparation of chromosome specimens. 15 abnormal karyotypes of peripheral blood were found in peripheral blood chromosomes. 84 abnormal karyotypes were found in amniotic fluid chromosome with the screeing positive rate of 15.52%. There are 99 cases of abnormal chromosome karyotypes. The results showed that Chromosome examination can detect some related chromosome diseases timely, in order to identify its genetic diagnosis more clearly, avoid blind treatment, and reduce the birth of children with chromosomal abnormalities effectively.

Key words: chromosome karyotype analysis, chromosomal abnormalities, prenatal diagnosis, chromosome examination

CLC Number: 

  • Q343
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